interleukin-8-251 a/t and cxcr2 +1208 c/t genes polymorphisms in chronic rhinosinusitis

introduction:  il-8 is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of chronic rhinosinusitis (crs) as well as nasal polyposis (np). the ability of individuals in producing il-8 is partially determined by il-8-251 a/t polymorphism. hence, the aim of the present study was to investigate the association between il-8-251 a/t and cxcr2 +1208 c/t genes polymorphisms and susceptibility to crs and np. materials and methods: two hundred and forty fivecrs patients and 204 healthy controls were included in this study. crs patients were categorized by the existence or absence of np. il-8 promoter-251 a/t and cxcr2 +1208 c/t gene polymorphisms were genotyped via the allele specific pcr (as-pcr) method. results: while no remarkable difference was demonstrated between patients and controls for both cxcr2 +1208 c/t and il-8 -251 a/t polymorphisms, a significant increase in il-8-251 aa genotype was detected in crs patients with np compared to those without it (29.3% and 16.2%, respectively; p=0.03). interestingly, this association got far stronger when only non-asthmatic crs patients were taken into consideration (p=0.001). conclusion: the results of the present study indicate that the inheritance of il-8-251 aallele is associated significantly with np development in crs patients. therefore, np formation might be a result of the exposure to an intense inflammatory environment, which is more likely in genetically susceptible crs patients.